09/08/2014
Current status of project: The scope is in development. A general overview of the project has been developed, as well as a outline of the scope.
Work planned for next week: Conference call at 2 today with client, Dr. Hickman, to determine the direct contact with the lab and specific needs and requirement of the client. After this meeting, a final draft of the scope will be created and submitted. Then, our group will begin creating metrics to quantify the needs of the client.
Anything needed from client or TA or instructor to continue work: From client: specific needs for the housing and details for the creation of the scope (should be gathered at conference call at 2 today).
Current status of project: The scope is in development. A general overview of the project has been developed, as well as a outline of the scope.
Work planned for next week: Conference call at 2 today with client, Dr. Hickman, to determine the direct contact with the lab and specific needs and requirement of the client. After this meeting, a final draft of the scope will be created and submitted. Then, our group will begin creating metrics to quantify the needs of the client.
Anything needed from client or TA or instructor to continue work: From client: specific needs for the housing and details for the creation of the scope (should be gathered at conference call at 2 today).
9/22/2014
Because of the report due on Friday, the literature search and preliminary analysis has been completed. Eric also has given the preliminary presentation. The project is now moving into the beginnings of the brainstorming of solutions and mathematical analysis.
This week, we will be beginning the mathematical calculations needed to satisfy the specific requirements dealing with physiologic matching and microfluidics. We will also be having a conference call with Dr. Hickman to discuss the possible dropping of several requirements.
From Dr. Hickman, we will be receiving feedback this week from our preliminary report, most importantly discussing the possibility of dropping some of the requirements listed by his group, namely dealing with materials for the design.
Because of the report due on Friday, the literature search and preliminary analysis has been completed. Eric also has given the preliminary presentation. The project is now moving into the beginnings of the brainstorming of solutions and mathematical analysis.
This week, we will be beginning the mathematical calculations needed to satisfy the specific requirements dealing with physiologic matching and microfluidics. We will also be having a conference call with Dr. Hickman to discuss the possible dropping of several requirements.
From Dr. Hickman, we will be receiving feedback this week from our preliminary report, most importantly discussing the possibility of dropping some of the requirements listed by his group, namely dealing with materials for the design.
9/29/2014
The project has progressed into the brainstorming, microfluidic analysis, and website design portions of the project. The variable elements of the design have been discussed, so that potential design ideas can be categorized as they are brainstormed. The mathematical analysis has begun, but we are waiting on more information about cell plating and some other design elements from our client before we can proceed. The website is in the very beginning stages of development, mostly just discussion on what we want, where/how we would host it, and the ways we can accomplish those goals.
This week, we will hopefully be having a conference call with Dr. Hickman about those design elements, how we narrowed the scope, and general updates on the project. The portions of the project mentioned above will continue to be worked on, and we will begin more concrete brainstorming.
From Dr. Hickman, we need information on cell plating densities, and feedback on which of the design specifications are most important for his group in the final design.
The project has progressed into the brainstorming, microfluidic analysis, and website design portions of the project. The variable elements of the design have been discussed, so that potential design ideas can be categorized as they are brainstormed. The mathematical analysis has begun, but we are waiting on more information about cell plating and some other design elements from our client before we can proceed. The website is in the very beginning stages of development, mostly just discussion on what we want, where/how we would host it, and the ways we can accomplish those goals.
This week, we will hopefully be having a conference call with Dr. Hickman about those design elements, how we narrowed the scope, and general updates on the project. The portions of the project mentioned above will continue to be worked on, and we will begin more concrete brainstorming.
From Dr. Hickman, we need information on cell plating densities, and feedback on which of the design specifications are most important for his group in the final design.
10/06/2014
This past Friday, our group had a Skype meeting with Balaji (while Dr. Hickman was travelling). In addition to updating him on the status of our project, we obtained some very important information from him. Namely, the relative importance of different design parameters (shear stress, liquid-to-cell ratio, and residence times). Finally, we created a website for our project (http://wu401group12.weebly.com/).
In the upcoming week, we will begin specifying chamber dimensions in order to meet our parameters, and will bring our website (which is currently very basic) up to date with our current progress.
This week Balaji will send us typical cell plating densities so that we can begin planning the exact chamber dimensions in order to meet the specifications - he will obtain this information from other members of the lab and other collaborators who have done more work with the actual cell culturing portion of this project.
This past Friday, our group had a Skype meeting with Balaji (while Dr. Hickman was travelling). In addition to updating him on the status of our project, we obtained some very important information from him. Namely, the relative importance of different design parameters (shear stress, liquid-to-cell ratio, and residence times). Finally, we created a website for our project (http://wu401group12.weebly.com/).
In the upcoming week, we will begin specifying chamber dimensions in order to meet our parameters, and will bring our website (which is currently very basic) up to date with our current progress.
This week Balaji will send us typical cell plating densities so that we can begin planning the exact chamber dimensions in order to meet the specifications - he will obtain this information from other members of the lab and other collaborators who have done more work with the actual cell culturing portion of this project.
10/13/14
This week, our group has begun making preliminary calculations for chamber dimensions, flow rates, and fluid resistances in order to meet our specifications. Since we are still awaiting further information from our client, our calculations cannot be complete and will contain an unsolved variable (which will depend on the relative cell densities of the four cell types). As of this report the main calculations that have been completed are for the shear stress experienced by the cells (which was identified by our client as the most important design parameter).
In the upcoming week, we will continue to expand on our calculations, which will include relative flow rates (governed by resistance), and liquid residence time (governed by fluid velocity and chamber length). We will also continue to bring our website up to date. Finally, we hope to set up another video conference call with our client to keep them up-to-date on the status of our project.
As of now, we are still waiting to hear back from Balaji with specific cell plating/cell growth densities.
This week, our group has begun making preliminary calculations for chamber dimensions, flow rates, and fluid resistances in order to meet our specifications. Since we are still awaiting further information from our client, our calculations cannot be complete and will contain an unsolved variable (which will depend on the relative cell densities of the four cell types). As of this report the main calculations that have been completed are for the shear stress experienced by the cells (which was identified by our client as the most important design parameter).
In the upcoming week, we will continue to expand on our calculations, which will include relative flow rates (governed by resistance), and liquid residence time (governed by fluid velocity and chamber length). We will also continue to bring our website up to date. Finally, we hope to set up another video conference call with our client to keep them up-to-date on the status of our project.
As of now, we are still waiting to hear back from Balaji with specific cell plating/cell growth densities.
10/20/14
This week, our group has completed some of the calculations necessary to create our design (specifically, we have calculated the chamber dimensions). We did significant research and analysis on different design alternatives for various portions of the design,and have completed the first draft of our progress report. Monday morning we met with Professor Klaesner to go over our first draft and answer some specific questions about the report.
In the upcoming week, we will finish our progress report, meeting with Rebecca on Tuesday afternoon. Over the weekend, we will complete the presentation for the progress report.
This week, our group has completed some of the calculations necessary to create our design (specifically, we have calculated the chamber dimensions). We did significant research and analysis on different design alternatives for various portions of the design,and have completed the first draft of our progress report. Monday morning we met with Professor Klaesner to go over our first draft and answer some specific questions about the report.
In the upcoming week, we will finish our progress report, meeting with Rebecca on Tuesday afternoon. Over the weekend, we will complete the presentation for the progress report.
10/27/14
This week, our group finished putting together our progress report. We finished creating our Pugh charts for design alternatives and met with both Rebecca Gilson and Dr. Klaesner to receive input and ask questions on our rough draft. We then finished editing our report, and Chase began preparing for his presentation on Wednesday.
Over the next week, we will begin to analyze our chosen solution to get ready for the final stages of the project, and prepare to create a CAD model for our chip design.
This week, our group finished putting together our progress report. We finished creating our Pugh charts for design alternatives and met with both Rebecca Gilson and Dr. Klaesner to receive input and ask questions on our rough draft. We then finished editing our report, and Chase began preparing for his presentation on Wednesday.
Over the next week, we will begin to analyze our chosen solution to get ready for the final stages of the project, and prepare to create a CAD model for our chip design.
11/03/14
This week, our group began analyzing our chosen solution to ensure that we are ready to begin creating our design in autoCAD. We've been double checking our physical parameters to ensure that they are close to physiological values, and we have been researching the process of creating mCCA silicon chips to determine if we will encounter any unexpected problems.
Over the next week, we will begin to create a CAD model for our chip design.
This week, our group began analyzing our chosen solution to ensure that we are ready to begin creating our design in autoCAD. We've been double checking our physical parameters to ensure that they are close to physiological values, and we have been researching the process of creating mCCA silicon chips to determine if we will encounter any unexpected problems.
Over the next week, we will begin to create a CAD model for our chip design.
11/10/14
This week, our group began autoCAD modeling of our solution, as well as the determining of specific layouts of the housing. Although we have determined certain parameters such as chamber size and channel length, we must still determine how exactly to construct the array such that these parameters are met (i.e. the specific layout of the chambers, channels, inlet, and outlet).
In the coming weeks we will be finalizing the design questions mentioned above and completing a model of the array.
This week, our group began autoCAD modeling of our solution, as well as the determining of specific layouts of the housing. Although we have determined certain parameters such as chamber size and channel length, we must still determine how exactly to construct the array such that these parameters are met (i.e. the specific layout of the chambers, channels, inlet, and outlet).
In the coming weeks we will be finalizing the design questions mentioned above and completing a model of the array.